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William Lubell

William Lubell
University of Montreal

Talk Title

Conception of Prostaglandin F2α Receptor Allosteric Modulators that Delay Preterm Birth by Harnessing the Paired Utility of Aza-Amino Acyl Proline and Indolizidinone Amino Acid Residues for Peptide Mimicry

Aza-amino acyl prolines and indolizidinone amino acids share common conformational preferences as demonstrated in second mitochondria-derived activator of caspase protein peptidomimetics, in calcitonin gene-related peptide antagonists, and in modulators of the prostaglandin-F2α receptor, FP.

Systematic study of the conformation and side chain functions of the central turn dipeptide residue of FP modulators has …