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Featured Speaker

Marina Rubini

Marina Rubini
College Lecturer/Assistant Professor
University College Dublin

Talk Title

The Impact of Fluoroproline Isomers on the Folding and Thermodynamic Stability of Globular Proteins

4-substituted proline analogues are of particular interest for investigating protein folding kinetics and thermodynamic stability, as substituents at the Cγ atom of proline have a strong effect on the two main conformational equilibria of proline residues in polypeptides, namely the endo/exo ring puckering of the proline ring and the cis/trans equilibrium of prolyl peptide bonds. The insta…