University of Kwazulu-Natal
Dissecting the SPPS Methodology: Resins, Handles, Coupling Reagents, Protecting Groups, Reagents, and Strategies
Recent years have witnessed a significant increase in the number of peptides based on Active Pharmaceutical Ingredients, APIs. Furthermore, peptides on the market have evolved from being small and linear, with approximately 10 amino acids, to being much more complex. Thus, regulatory agencies are increasingly approving cyclic peptides, longer peptides, 20-40 amino acids, and peptides containing fatty acids. In research and industrial sectors, all these peptides are prepared using the solid-phase peptide synthesis, SPPS, strategy, which was developed by Merrifield in the early 60s.
This renaissance of peptides in the drug market has been, in part, possible thanks to the continuous work carried out by several groups working on diverse methodological aspects of SPPS.
In this presentation, I will go over the most important contributions to SPPS methodology made by my group in recent years. I will pay special attention to discussing resins, handles, coupling reagents, protecting schemes, and synthetic strategies for both research and industrial purposes.