Co-Director, Small Molecule Discovery Center
University of California at San Francisco
San Francisco, CA
Tackling Challenging Drug Targets using Fragment-Based Ligand Discovery
Many potential drug targets are known to be relevant for disease, but have been ‘undruggable’ by current approaches. Our lab seeks to understand to what extent this failure has been due to the features of the biological target vs the methodologies used to discover small-molecule modulators.
In particular, we have focused on protein-protein interactions and the larger networks controlled by these interactions. This presentation will describe the use of disulfide trapping to discover first-in-class compounds that modulate ‘challenging’ targets, including protease inhibitors and protein-protein stabilizing compounds.
AffiliationsUniversity of California, San Francisco