Jane Dyson

Jane Dyson

Professor
The Scripps Research Institute
La Jolla, CA
USA
 858-784-2223
 dyson@scripps.edu

Abstract

Intrinsically Disordered Proteins – Vital Peptide Cogs in Metabolic Machines

Disordered proteins and disordered segments of larger proteins play a vital role in protein-protein interactions in many different metabolic processes. Cellular signaling is vitally dependent on the presence of disorder in the interacting proteins1 – the same polypeptide can make interactions with many partners, leading to pathway cross-talk, and combinatorial post-translational modifications turn signals on and off.


Figure

We study disordered proteins and their interactions in solution, primarily using NMR spectroscopy. Our interest has been in the molecular basis of the interactions and the mechanisms by which cellular signaling is controlled. Signaling pathways such as the hypoxia response2 and the role of viral oncoproteins in virus-induced oncogenesis3, 4 are examples that show the central importance of disorder in cellular signaling pathways.

Authors

H. Jane Dyson and Peter E. Wright

Affiliations

Department of Integrative Structural and Computational Biology, Scripps Research, 10550 North Torrey Pines Road, La Jolla CA 92037

Citations

1 Intrinsically disordered proteins in cellular signalling and regulation. P.E. Wright and H.J. Dyson, Nat. Rev. Mol. Cell Biol., 2015, 16, 18-29
2 Hypersensitive termination of the hypoxic response by a disordered protein switch. R.B. Berlow, H.J. Dyson and P.E. Wright, Nature 543, 2017, 447-451
3 The high-risk HPV16 E7 oncoprotein mediates interaction between the transcriptional coactivator CBP and the retinoblastoma protein pRb. A.L. Jansma, M.A. Martinez-Yamout, R. Liao, P. Sun, H.J. Dyson and P.E. Wright, J. Mol. Biol., 2014, 426, 4030-4048
4 Structural basis for cooperative regulation of KIX-mediated transcription pathways by the HTLV1 HBZ activation domain. K. Yang, R.L. Stanfield, M.A. Martinez-Yamout, H.J. Dyson and P.E. Wright, Proc. Natl. Acad. Sci. USA, 2018, 115, 10040-10045

Lecture Images

Jane Dyson presenting at APS2019 Jane Dyson presenting at APS2019 Jane Dyson presenting at APS2019