Tom W. Muir

Tom Muir

Professor of Chemistry
Department Chair
Princeton University
Princeton, NJ
USA
 609-258-5778
 muir@princeton.edu

Abstract

Painting Chromatin with Synthetic Protein Chemistry

Understanding protein function is at the heart of experimental biology. Perhaps one of grandest contemporary challenges in this area is to catalogue and then functionally characterize protein posttranslational modifications, PTMs. Modern analytical techniques reveal that most, if not all, proteins are modified at some point; it is nature’s way of imposing functional diversity on a polypeptide chain. Understanding the structural and functional consequences of all of these PTMs is a devilishly hard problem.

While standard molecular biology methods are of limited utility in this regard, modern protein chemistry has provided powerful methods that allow the detailed interrogation of protein PTMs.

In this lecture, I will highlight how these tools can be used to probe a series of problems in chromatin biology. In particular, I will discuss how histone PTMs regulate chromatin structure and function and how dysregulation of these processes can lead to disease.

Authors

Tom Muir

Affiliations

Princeton University

Lecture Images

Tom Muir presenting at APS2019 Tom Muir presenting at APS2019 Tom Muir presenting at APS2019