University of Padova
Self-Assembly of Peptides on Gold Nanoparticles for Molecular Recognition and Catalysis
The exquisite properties of proteins in terms of molecular recognition and catalysis derive in large part from their size and structural complexity. Their size permits the presence of internal cavities, which are well-shielded from the bulk solvent, and permit additional advantages like allosteric control by secondary binding sites and multivalent interactions to drive protein-protein interactions. The fact that all proteins are composed of a very limited number of amino acids renders these structures even more fascinating.
A strong impetus exists to develop synthetic structures able to match the size and complexity of proteins for applications in diagnostics, medicine and materials science. The advantage of synthetic structures is the ability to design the desired structure and the possibility to include non-natural building blocks. Here, we show that the self-assembly of peptides on Au nanoparticles is an attractive tool to obtain functional protein-like nanostructures for application in molecular recognition and catalysis.
AuthorsLeonard J. Prins
AffiliationsDepartment of Chemical Sciences, University of Padova, Padova, Italy
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